Preheat oven to 350°F and grease two 9x5-inch loaf pans. Set aside.

Toss blueberries with the 2 tablespoons of flour. Set aside.

In a large mixing bowl, beat the butter, cream cheese, sugar, and vanilla with an electric mixer until smooth. Add eggs one at a time, mixing well after each addition.

In a separate bowl, stir together the remaining 2 cups flour, baking powder, and salt. Gradually mix into the wet ingredients until thoroughly incorporated.

Gently fold in blueberries and pour batter into prepared loaf pans. Bake until a toothpick inserted into the center comes out clean, 45-55 minutes.

Let cool on wire rack for 10 minutes before running a knife along the edges and inverting out onto wire rack to cool completely.

Slice, serve, and enjoy!